The Powerpuff Girls episode Child Fearing
August 18, 2000
The second segment of the second episode of season 3 (Episode #28b) features a videogame clearly based on The Legend of Zelda: Ocarina of Time, featuring a character looking like Link followed by a fairy similar to Navi, and also constantly yelling "hey!" like her. There's even an interface based on the original game's.
The Major of Townsville is seen trying to play the game, but ending up crashing into the wall, being smashed by a boulder and even killing the fairy by accident. The controller he uses to play is also clearly based on the Nintendo 64 controller.
The creators of The Powerpuff Girls held no right over Nintendo's Zelda, but they only included a parody of the game.